Table 2.

Pharmacokinetic variables for lapatinib and letrozole

VariablesLapatinib alone (n = 9)*Lapatinib + letrozole (n = 10)*Comparison
AUCτ (h μg/mL)31.9 (17.2-59.2)27.0 (13.3-54.8)0.84 (0.62-1.13)
Cmax (μg/mL)2.47 (1.47-4.13)1.94 (1.13-3.34)0.78 (0.57-1.06)
tmax (h)3.00 (0.00-12.2)3.00 (2.50-12.0)0.02 (-0.37-1.75)
Cτ (μg/mL)0.78 (0.37-1.66)0.72 (0.30-1.73)0.90 (0.63-1.28)
Variables
Letrozole alone (n = 8)*
Letrozole + lapatinib (n = 8)*
Comparison
AUCτ (h μg/mL)2.23 (1.34-3.71)2.09 (1.30-3.34)0.94 (0.79-1.11)
Cmax (μg/mL)0.14 (0.08-0.22)0.12 (0.08-0.19)0.90 (0.79-1.02)
tmax (h)1.75 (1.50-24.0)1.25 (0.00-6.00)-1.75 (-12.0-1.00)
Cτ (μg/mL)0.09 (0.05-0.17)0.08 (0.05-0.13)0.86 (0.71-1.05)
  • * Geometric mean (95% confidence interval), except median (range) for tmax.

  • Geometric least-squares mean ratio (90% confidence interval), except median difference and 90% confidence interval for tmax.