Table 3.

Comparison of clinical and pathologic features by tumor vasculature B7-H3 expression for 743 ccRCC patients

FeatureTumor vasculature B7-H3 expression, n (%)
P
Absent, n = 36Focal, n = 237Moderate, n = 197Diffuse, n = 273
Age at surgery (y)
    <6521 (58.3)122 (51.5)93 (47.2)142 (52.0)0.565
    ≥6515 (41.7)115 (48.5)104 (52.8)131 (48.0)
Gender
    Female12 (33.3)85 (35.9)78 (39.6)92 (33.7)0.605
    Male24 (66.7)152 (64.1)119 (60.4)181 (66.3)
Symptoms at presentation
    No19 (52.8)103 (43.5)70 (35.5)72 (26.4)<0.001
    Yes17 (47.2)134 (56.5)127 (64.5)201 (73.6)
Constitutional symptoms at presentation
    No33 (91.7)202 (85.2)149 (75.6)161 (59.0)<0.001
    Yes3 (8.3)35 (14.8)48 (24.4)112 (41.0)
ECOG performance status
    033 (91.7)216 (91.1)169 (85.8)254 (93.0)0.064
    ≥13 (8.3)21 (8.9)28 (14.2)19 (7.0)
Tumor thrombus
    None33 (91.7)208 (87.8)156 (79.2)201 (73.6)<0.001
    Level 02 (5.6)19 (8.0)23 (11.7)31 (11.4)
    Level I-IV1 (2.8)10 (4.2)18 (9.1)41 (15.0)
Primary tumor size (cm)
    <525 (69.4)93 (39.2)66 (33.5)54 (19.8)<0.001
    5-<72 (5.6)58 (24.5)47 (23.9)51 (18.7)
    7-<103 (8.3)45 (19.0)41 (20.8)76 (27.8)
    ≥106 (16.7)41 (17.3)43 (21.8)92 (33.7)
2002 Primary tumor classification
    pT1a24 (66.7)70 (29.5)46 (23.4)39 (14.3)<0.001
    pT1b2 (5.6)72 (30.4)69 (35.0)59 (21.6)
    pT25 (13.9)48 (20.3)28 (14.2)69 (25.3)
    pT3a2 (5.6)17 (7.2)12 (6.1)32 (11.7)
    pT3b3 (8.3)27 (11.4)38 (19.3)60 (22.0)
    pT3c02 (0.8)3 (1.5)7 (2.6)
    pT401 (0.4)1 (0.5)7 (2.6)
Regional lymph node involvement
    pNX and pN036 (100.0)233 (98.3)189 (95.9)254 (93.0)0.015
    pN1 and pN204 (1.7)8 (4.1)19 (7.0)
Distant metastases
    pM033 (91.7)222 (93.7)181 (91.9)225 (82.4)<0.001
    pM13 (8.3)15 (6.3)16 (8.1)48 (17.6)
2002 TNM stage groupings
    I26 (72.2)137 (57.8)110 (55.8)93 (34.1)<0.001
    II3 (8.3)42 (17.7)25 (12.7)53 (19.4)
    III4 (11.1)41 (17.3)42 (21.3)74 (27.1)
    IV3 (8.3)17 (7.2)20 (10.2)53 (19.4)
Nuclear grade
    16 (16.7)25 (10.6)14 (7.1)5 (1.8)<0.001
    215 (41.7)131 (55.3)88 (44.7)99 (36.3)
    315 (41.7)71 (30.0)78 (39.6)131 (48.0)
    4010 (4.2)17 (8.6)238 (13.9)
Coagulative tumor necrosis
    No29 (80.6)200 (84.4)141 (71.6)151 (55.3)<0.001
    Yes7 (19.4)37 (15.6)56 (28.4)122 (44.7)
Sarcomatoid differentiation
    No36 (100.0)231 (97.5)186 (94.4)252 (92.3)0.029
    Yes06 (2.5)11 (5.6)21 (7.7)