Table 2.

Univariate analysis of different gene classifiers per molecular subgroup of untreated breast cancer patients

ER−/HER2-
HER2+
ER+/HER2-
HR (95% CI)PNo. patientsHR (95% CI)PNo. patientsHR (95% CI)PNo. patients
GENE701.12 (0.73-1.72)0.601541.29 (0.75-2.20)0.361202.11 (1.67-2.66)3 × 10−10566
GENE761.30 (0.78-2.15)0.32990.81 (0.49-1.34)0.42851.52 (1.24-1.88)2 × 10−5422
P531.01 (0.42-2.42)0.981631.04 (0.51-2.11)0.921262.23 (1.64-3.03)4 × 10−7605
WOUND0.90 (0.65-1.26)0.541601.24 (0.79-1.93)0.351261.48 (1.25-1.75)5 × 10−6598
GGI0.78 (0.44-1.36)0.381650.79 (0.40-1.53)0.481263.16 (2.46-4.06)2 × 10−19598
ONCOTYPE0.86 (0.36-2.08)0.741561.00 (0.50-2.02)1.001264.79 (3.43-6.68)3 × 10−20605
IGS1.08 (0.73-1.61)0.701690.96 (0.63-1.46)0.851262.12 (1.73-2.60)6 × 10−13605
  • NOTE: All signatures are considered here as continuous variables. GENE70, 70-gene signature (1, 2); GENE76, 76-gene signature (3, 4); P53, p53 signature (9); WOUND, Wound response signature (5, 6); GGI, Genomic Grade Index (7); ONCOTYPE, 21-gene Recurrence Score (8); IGS, 186-gene “invasiveness” gene signature (10).