Table 1.

Prognostic significance of actinin-4 expression in 173 cases of invasive ductal carcinoma of the pancreas

Univariate analysis*
Multivariate analysis*
Hazard ratio95% Confidence intervalPHazard ratio95% Confidence intervalP
Age (y)
    <65/≥651.180.85-1.650.321584
Gender
    Male/female1.120.80-1.570.515322
UICC stage
    I-II/III-IV2.591.31-5.120.0061911.350.59-3.080.471917
Extent of primary tumor
    T1-2/T3-41.811.16-2.820.0085280.860.52-1.440.572695
Lymph node metastasis
    N0/N12.731.82-4.080.0000011.961.20-3.190.007271
Distant metastasis
    M0/M12.401.68-3.440.0000021.731.18-2.540.005023
Lymphatic invasion§
    ly0/ly1-32.061.44-2.950.0000761.541.03-2.280.033537
Intrapancreatic nerve invasion§
    ne0/ne1-31.260.89-1.770.189521
Macroscopic type§
    Nodular/infiltrative1.280.91-1.800.162522
Cancer-stroma relationship§
    Medullary and intermediate/scirrhous1.140.81-1.600.458187
Expression of actinin-4
    Positive/negative2.271.57-3.270.0000122.331.61-3.390.000009
  • * Univariate and multivariate analyses with Cox proportional hazards model.

  • P < 0.01 was considered statistically significant.

  • Based on the International Union Against Cancer tumor-node-metastasis classification (6th edition).

  • § Based on the Japan Pancreas Society's classification of pancreatic carcinoma (2nd English edition).