Table 3.

Pretreatment factors: association with prognosis (two-tailed P values)

IL-2 alone
IL-2 + vaccine
ResponseSurvival*ResponseSurvival*
Sex≥0.1≥0.1≥0.1≥0.1
Race≥0.1≥0.1≥0.1≥0.1
Eastern Cooperative Oncology Group score (0 vs 1-2)≥0.10.03≥0.1≥0.1
Prior treatment
    Immunotherapy≥0.1≥0.1≥0.1≥0.1
    IFN-α≥0.1≥0.1≥0.1≥0.1
    Radiotherapy≥0.10.040.01≥0.1
    Chemotherapy≥0.1≥0.1≥0.1≥0.1
    Hormonal therapy≥0.1≥0.1≥0.1≥0.1
Baseline laboratory values
    WBC count≥0.1≥0.1≥0.1≥0.1
    Lymphocytes count≥0.1≥0.10.05≥0.1
    Eosinophil count0.02≥0.10.08≥0.1
    Platelet count≥0.1≥0.1≥0.1≥0.1
    Bilirubin≥0.1≥0.1≥0.1≥0.1
    Creatinine≥0.1≥0.10.04≥0.1
    TSH≥0.1≥0.1≥0.1≥0.1
    FT4≥0.1≥0.1≥0.1≥0.1
No. metastatic sites0.020.06<0.0001<0.0001
  • * Survival at 4 y.

  • Lower in responders.