Table 1.

Growth-inhibitory activity of ART compounds

Cell lineInhibitory concentration (╬╝mol/L)ARTDHAARMARS
7702IC203.63.87.97.3
IC5060.9167.7492>500
IC80>500>500>500>500
HepG2 (p53 wild-type)IC201.31.22.61.3
IC5013.9813.3554.820.5
IC80145.1145.8>500338.2
Hep3B (p53 null)IC200.970.962.41.5
IC5010.410.351.539.4
IC80113.3110.7>500>500
Huh-7 (p53 mutant)IC200.70.71.20.6
IC508.99.631.49.22
IC80115.4130.9>500146.1
BEL-7404 (p53 mutant)IC200.90.72.41.0
IC509.99.331.7815.0
IC80107.1129.7>500215.4