Table 1.

Comparison of in vitro apoptosis induction of imatinib-sensitive PDGFRAΔDIM842-844 and imatinib-resistant PDGFRAD842V mutants expressed in the Ba/F3 cells

PDGFRAΔDIM842-844
PDGFRAD842V
Normal (%)Necrotic (%)Apoptotic (%)Normal (%)Necrotic (%)Apoptotic (%)
Vehicle85.195.784.27.67.4
Imatinib
    0.1 μmol/L71.815.112.985.96.86.6
    0.5 μmol/L60.920.818.187.74.77.3
Nilotinib
    0.1 μmol/L857.87.187.76.94.5
    0.5 μmol/L73.813.412.588.45.75.2
Sorafenib
    0.1 μmol/L74.114.111.587.96.65
    0.5 μmol/L66.516.716.889.45.94.5
Dasatinib
    0.1 μmol/L46.126.62777.913.38.3
    0.5 μmol/L39.330.328.959.424.115.4
IPI-504
    0.1 μmol/L73.114.612.180.311.96.5
    0.5 μmol/L48.428.622.137.837.822.8