Table 1.

Curcumin levels in mouse serum and liver

SampleConcentration applied (pmol)Post i.v. injection (h)Observed concentration (pmol)
Standard0.010NA0.010*
0.10NA0.100
1.00NA0.808
Standard, curcumin added to serum before extraction
    10 ng/250 μLNA0.2
    25 ng/250 μLNA0.5
    250 ng/250 μLNA4.5
Control mouse (serum plasma, 100 μL)NAND
DMSO curcumin (serum plasma, 100 μL)1ND
2ND
4ND
8ND
24ND
48ND
Liposomal curcumin (serum plasma, 100 μL)1ND
2>10
48.790
85.321
243.345
48ND
Control mouse (liver, 0.1 g)NAND
DMSO curcumin (liver, 0.1 g)10.024
20.041
40.063
Liposomal curcumin (liver, 0.1 g)10.028
20.070
40.009
  • Abbreviations: NA, not applicable; ND, not detectable.

  • * Minimum detection level using the liquid chromatography-mass spectrometric system.