Table 3.

Frequency of grades 3 and 4 toxicities, at least possibly related to study treatment, occurring during the first four cycles of study treatment, among patients in solid tumor cohort (n = 30)

ToxicityGrade 3, n (%)Grade 4, n (%)
Febrile neutropenia1 (3)1 (3)
Neutropenia5 (17)14 (47)
Lymphopenia10 (33)3 (10)
WBC count15 (50)6 (20)
Anemia9 (30)0
Thrombocytopenia2 (7)1 (3)
Aspartate transaminase or alanine transaminase elevation8 (27)1 (3)
Infection, without neutropenia1 (3)0
Hyponatremia01 (3)
Edema2 (7)0