Table 7.

Summary of patients with ataxia-dizziness delayed toxicity events (n = 5)

PatientAgeDiseaseDose levelNo. cycles received before toxicityAtaxia/dizziness gradeOutcome
143Ovary4132Resolved to grade 0 off study treatment
253Ovary462Resolved to grade 0 off study treatment
363Head and neck4122Resolved to grade 0 off study treatment
469Endometrial373Further evaluation detected brain metastases; ataxia event deemed unrelated to study treatment
574Ovary493Symptoms improved to grade 2 off study treatment
665Anaplastic thyroid3102Resolved to grade 0 off study treatment