Summary of patients with ataxia-dizziness delayed toxicity events (n = 5)
Patient | Age | Disease | Dose level | No. cycles received before toxicity | Ataxia/dizziness grade | Outcome |
---|---|---|---|---|---|---|
1 | 43 | Ovary | 4 | 13 | 2 | Resolved to grade 0 off study treatment |
2 | 53 | Ovary | 4 | 6 | 2 | Resolved to grade 0 off study treatment |
3 | 63 | Head and neck | 4 | 12 | 2 | Resolved to grade 0 off study treatment |
4 | 69 | Endometrial | 3 | 7 | 3 | Further evaluation detected brain metastases; ataxia event deemed unrelated to study treatment |
5 | 74 | Ovary | 4 | 9 | 3 | Symptoms improved to grade 2 off study treatment |
6 | 65 | Anaplastic thyroid | 3 | 10 | 2 | Resolved to grade 0 off study treatment |