Table 2.

Number of dose-limiting toxicities observed in each cohort (drug-related, first course)

5-AZA dose (mg/m2)No. of patientsGrade 3 or 4 toxicitiesNo. of patients
206
256
37.58Neutropenic fever1
477
596
7516Neutropenic fever3
946Neutropenic fever2
Thrombocytopenia1
Total557