Table 1.

Comparison of hypermethylation detection on tumor DNA (HNSCC patients) and salivary rinse samples (controls)

GeneTumor, case (n)Salivary rinses, control (n)P*Sensitivity, % (95% CI)Specificity, % (95% CI)
DCC135462<0.000177.8 (69.8-84.5)98.9 (97.5-99.7)
DAPK136451<0.000175.0 (66.9-82.0)96.2 (94.0-97.8)
TIMP3138450<0.000173.9 (65.8-81.0)92.9 (90.1-95.1)
ESR35119<0.000160.0 (42.1-76.1)98.3 (94.1-99.8)
CCNA1102444<0.000161.8 (51.6-71.2)97.1 (95.1-98.4)
CCND23597<0.000168.6 (50.7-83.2)89.7 (81.9-94.7)
MINT187296<0.000190.8 (82.7-96.0)66.2 (60.5-71.6)
MINT31136492<0.000136.8 (28.7-45.5)100 (99.4-100)
CDH177116<0.000190.9 (82.2-96.3)37.9 (29.1-47.4)
AIM17773<0.000123.4 (14.5-34.4)98.6 (92.6-100)
MGMT44239<0.000122.7 (11.5-37.8)95.0 (91.4-97.4)
p16136500<0.000113.2 (8.0-20.1)100 (99.4-100)
PGP9.5451120.00491.1 (78.8-97.5)30.4 (22.0-39.8)
RARB44350.00579.6 (64.7-90.2)51.4 (34.0-68.6)
HIC145460.026100 (93.6-100)13.0 (4.9-26.3)
RASSF1A44350.06311.4 (3.8-24.6)100 (91.8-100)
CALCA35300.209100 (91.8-100)6.7 (0.8-22.1)
TGFBR211440.26654.6 (23.4-83.3)25.0 (13.2-40.3)
S100A244350.39895.5 (84.5-99.4)11.4 (3.2-26.7)
RIZ144350.6946.8 (1.4-18.7)88.6 (73.3-96.8)
RBM64435>0.99997.7 (88.0-99.9)0 (0-8.2)
  • * Fisher's exact test for the association between gene methylation and HNSCC.