Table 3.

Comparison of hypermethylation detection on tumor DNA (HNSCC patients) and serum samples (controls)

GeneTumor case (n)Serum control (n)P*Sensitivity, % (95% CI)Specificity, % (95% CI)
HIC145373<0.0001100 (93.6-100)92.5 (89.3-95.0)
PGP9.545203<0.000191.1 (78.8-97.5)97.5 (94.4-99.2)
TGFBR242134<0.000188.1 (74.4-96.0)94.0 (88.6-97.4)
RARB4485<0.000179.6 (64.7-90.2)100 (96.5-100)
DCC135135<0.000177.8 (69.8-84.5)100 (97.8-100)
TIMP3138296<0.000173.9 (65.8-81.0)94.6 (91.4-96.9)
CCNA135284<0.000168.6 (51.6-71.2)98.2 (97.2-100)
CDH177320<0.000190.9 (82.2-96.3)73.1 (67.9-77.9)
CCND235284<0.000168.6 (50.7-83.2)98.2 (95.9-99.4)
ESR3520<0.000160.0 (42.1-76.1)100 (86.1-100)
MINT18719<0.000190.8 (82.7-96.0)68.4 (43.5-87.4)
MINT3113642<0.000136.8 (28.7-45.5)100 (93.1-100)
AIM17741<0.000123.4 (14.5-34.4)100 (93.0-100)
p16136102<0.000113.2 (8.0-20.1)100 (97.1-100)
CALCA35200.005100 (91.8-100)25.0 (8.7-49.1)
RASSF1A441040.00911.4 (3.8-24.6)99.0 (94.8-100)
RBM644180.02297.7 (88.0-100)22.2 (6.4-47.6)
S100A244120.19895.5 (84.5-99.4)16.7 (2.1-48.4)
RIZ144180.5506.8 (1.4-18.7)100 (84.7-100)
  • * Fisher's exact test for the association between gene methylation and HNSCC.