Table 1.

Dose escalation schedule

Dose levelDoxorubicin dose (mg/m2)Trabectedin dose (mg/m2)n*
−1500.90
1A600.94
1600.918
2601.113
3601.36
4751.30
  • * Dose escalation/de-escalation and dose modification schedules as specified in Materials and Methods.

  • Patients who had severe neutropenia in cycle 1 but without prophylactic G-CSF use.