Table 2.

Histologic subtypes of MMR-deficient ovarian cancers

ReferenceSample sizeSerousMucinousEndometrioidClear cell
HNPCC-associated ovarian cancers
    Aarnio et al., 1999 (40)134212
    Bewtra et al., 1992 (3)41012
    Crijnen et al., 2005 (13)2612141
    Ichikawa et al., 1999 (43)42110
    Stratton et al., 1999 (46)20110
    Watson et al., 2001 (47)79177137
MSI-H ovarian cancers
    Chiaravalli et al., 2001 (41)40310
    Dellas et al., 2004 (25)2011331
    Fujita et al., 1995 (26)82150
    Geisler et al., 2003 (10)2112260
    Gras et al., 2001 (11)20011
    King et al., 1995 (29)72021
    Sood et al., 2001 (35)137N/AN/AN/A
Ovarian cancers with loss of MMR protein expression
    Domanska et al., 2007 (42)60132
    Malander et al., 2006 (44)30101
    Rosen et al., 2006 (45)70012
  • Abbreviation: N/A, not applicable.

  • * Studies where only epithelial ovarian cancers were included, N/A (not applicable) is indicated in this column, as nonepithelial ovarian cancers were not included in these studies.

  • Unspecified adenocarcinomas and nonepithelial cancers were not included within the denominator.

  • Two histologic subtypes were unknown, thus not included in the percentage.