Dosing and toxicity summary
| Cohort | Dose AG014699 (mg/m2) | Dose temozolomide (mg/m2) | No. patients | Total no. cycles given | Dose-limiting toxicities and other grade 3/4 toxicity | |
|---|---|---|---|---|---|---|
| Part 1 | 1 | 1 | 100 | 3 | 30 | None |
| 2 | 2 | 100 | 4 | 11 | None | |
| 3 | 4 | 100 | 4 | 20 | None | |
| 4 | 8 | 100 | 4 | 5 | None | |
| 5 | 12 | 100 | 3 | 11 | None | |
| Part 2 | 6 | 12 | 135 | 3 | 6 | None |
| 7 | 12 | 170 | 3 | 10 | None | |
| 8 | 12 | 200 | 3 | 16 | None | |
| 9 | 18 | 200 | 6 | 21 | 1/6 + 3 C2 delay after grade 3 neutropenia |