Table 2.

Dosing and toxicity summary

CohortDose AG014699 (mg/m2)Dose temozolomide (mg/m2)No. patientsTotal no. cycles givenDose-limiting toxicities and other grade 3/4 toxicity
Part 111100330None
22100411None
34100420None
4810045None
512100311None
Part 261213536None
712170310None
812200316None
9182006211/6 + 3 C2 delay after grade 3 neutropenia