Table 2.

Toxicity

National Cancer Institute grade
1234
Hematologic
    Hemoglobin9 (16)3 (5)00
    Lymphopenia1 (2)4 (7)2 (4)0
    Neutrophils/granulocytes04 (7)26 (46)17 (30)
    Platelets1 (2)1 (2)00
    Transfusion: packed RBC35 (63)7 (12)2 (4)0
    Febrile neutropenia1 (2)01 (2)0
Cardiovascular
    Hypertension8 (14)1 (2)9 (16)0
    Pericardial effusion/pericarditis001 (2)0
    Phlebitis (superficial)2 (4)000
    Thrombosis/embolism1 (2)001 (2)
Constitutional
    Fatigue17 (30)27 (48)8 (14)0
    Fever (without neutropenia)13 (23)2 (4)00
    Alopecia14 (25)9 (16)00
    Rash/desquamation7 (12)2 (4)00
    Arthralgia (joint pain)11 (20)8 (14)1 (2)0
    Myalgia (muscle pain)10 (18)5 (9)1 (2)0
    Bone pain6 (11)2 (4)1 (2)0
    Proteinuria13 (23)3 (5)1 (2)0
Gastrointestinal
    Constipation17 (30)8 (14)1 (2)0
    Diarrhea14 (25)6 (11)00
    Nausea20 (36)7 (12)5 (9)0
    Stomatitis/pharyngitis15 (27)3 (5)00
    Vomiting16 (29)2 (4)6 (11)0
Bleeding
    Hemorrhage7 (12)000
    Epistaxis12 (21)01(2)0
Neurologic
    Headache14 (25)9 (16)2 (4)0
    Neuropathy, motor4 (7)2 (4)00
    Neuropathy, sensory25 (45)3 (5)1 (2)0