Table 2.

Dose escalation and occurrence of DLTs

Dose levelLapatinib (mg)Topotecan (mg/m2)No. patientsNo. DLTs
Cohort 1
    0*7502.430
    17503.230
    21,0003.230
    31,2503.261
    41,2504.032
Cohort 2
    0*1,0003.230
    11,2503.260
  • * Starting dose level.