Table 1.

Comparison of gene expression differences between MSI and MSS colorectal cancers across multiple studies

Primary colorectal cancers (MSI vs MSS), n (%)
Aarhus University Hospital
Watanabe et al.Up-regulatedDown-regulatedP < 0.001
    Up-regulated3,448 (51.2)49 (0.7)
    Down-regulated83 (1.2)3,152 (46.8)
Aarhus University Hospital
Koinuma et al.Up-regulatedDown-regulatedP < 0.001
    Up-regulated553 (48.0)24 (2.1)
    Down-regulated46 (4.0)528 (45.9)
Watanabe et al.
Koinuma et al.Up-regulatedDown-regulatedP < 0.001
    Up-regulated528 (49.9)25 (2.4)
    Down-regulated27 (2.6)478 (45.2)
  • NOTE: Analysis was done on 48 MSI and 47 MSS cases analyzed at Aarhus University Hospital, 24 MSI and 36 MSS cases from Watanabe et al. (16), and 10 MSI and 10 MSS cases from Koinuma et al. (13). For each cohort, genes (probe sets) differentially expressed between MSI and MSS cases were identified using the Wilcoxon rank-sum test and P < 0.05. For genes overlapping between cohorts, consistency of up-regulation or down-regulation in MSI cancers was assessed using the χ2 test.