Table 1.

Complete blood count and immunohistochemical results from vehicle- and rapamycin-treated animals

BloodVehicleRapamycin
Average (n = 7)Average (n = 7)
WBC count (K/μL)10.4 (4.7)11.4 (4.7)
RBC count (M/μL)6.3 (2.8)7.2 (2.9)
Hemoglobin (g/dL)11.3 (5.1)12.7 (5.2)
Hematocrit (%)33.7 (15.1)35.1 (14.3)
MCV (fL)57.4 (25.7)49.9 (20.4)
Platelets (K/μL)1,437.6 (642.9)1,125.0 (459.3)
Polys (%)44.7 (20.0)37.1 (15.1)
Lymphocytes (%)44.3 (19.8)43.6 (17.8)
Monocytes (%)8.7 (3.9)15.9 (6.5)
Eosinophils (%)0.9 (0.4)0.5 (0.2)
Basophils (%)1.6 (0.7)3.0 (1.2)
Tumor tissues (immunohistochemistry)VehicleRapamycin
Average* (n = 5)Average* (n = 5)
T cells (CD3+)96.4 (17.1)97.6 (11.8)
Macrophage (F4/80+)221.6 (10.5)230.8 (41.2)
  • NOTE: Blood samples were collected from mice at advanced stages of tumor progression, as described in Fig. 2, after prolonged (6 wk) treatment with rapamycin and vehicle (see Materials and Methods). Standard complete blood cell components were analyzed. Immunohistochemistry for T cells markers (CD3+) and macrophage markers (F4/80+) was analyzed in tissue from the corresponding vehicle- and rapamycin-treated animals. Numbers are the mean (average) ± SE.

    Abbreviations: MCV, mean corpuscular volume; Polys, polymorphonuclear leukocytes.

  • * Arbitrary unit.