Table 1.

Patients characteristics and gene expression

VEGFAng-1Ang-2Tie2
Median (range)PMedian (range)PMedian (range)PMedian (range)P
Age, 71.6 (36-96), y
    ≤65 (n = 51)9.11 (0.77-76.11)0.1950.30 (0.005-3.34)0.01509 (68-3,373)0.0891.46 (0.11-14.47)0.110
    >65 (n = 62)6.5 (0.17-101.83)0.13 (0.001-1.21)336 (7-3,072)0.86 (0.04-12.64)
Gender
    Male (n = 88)8.86 (0.17-101.83)0.3340.29 (0.01-2.01)0.164386 (7-3,373)0.821.59 (0.19-6.66)0.245
    Female (n = 25)7.23 (0.42-82.71)0.17 (0.001-3.34)401 (42-3,126)0.97 (0.04-14.47)
Stage
    Ta (n = 31)25.41 (1.06-78.25)0.07 (0.001-3.34)948 (110-3,126)0.86 (0.27-14.47)
    T1 (n = 17)8.11 (1.19-101.83)0.10 (0.01-0.85)322 (68-2,427)0.76 (0.16-11.47)
    T2 (n = 13)7.08 (1.03-51.09)0.22 (0.02-2.43)316 (113-1,783)1.47 (0.04-10.09)
    T3 (n = 39)4.52 (0.77-76.11)0.31 (0.01-2.11)326 (20-3,009)1.77 (0.23-12.64)
    T4 (n = 13)4.89 (0.17-42.96)0.36 (0.005-2.01)189 (7-3,373)1.06 (0.18-6.66)
    Noninvasive (n = 48)13.55 (1.1 -101.83)<0.0010.31 (0.01-2.11)<0.001671 (68-3,126)0.0010.84 (0.16-14.47)0.071
    Invasive (n = 65)4.92 (0.17-76.11)0.36 (0.005-2.01)285 (7-3,373)1.49 (0.04-12.64)
Grade
    1 (n = 17)18.32 (1.06-101.83)0.05 (0.005-3.34)626 (110-2,427)0.84 (0.16-14.47)
    2 (n = 40)9.04 (1.03-82.71)0.11 (0.001-1.21)426 (20-3,126)0.90 (0.29-7.67)
    3 (n = 56)5.98 (0.17-76.11)0.36 (0.005-2.43)336 (7-3,373)1.57 (0.04-12.64)
    Low-grade (grade 1-2; n = 57)10.85 (1.03-101.83)0.0230.09 (0.001-3.34)<0.001519 (20-3,126)0.0750.86 (0.16-14.47)0.064
    High-grade (grade 3; n = 56)5.98 (0.17-76.11)0.36 (0.005-2.43)335 (7-3,373)1.57 (0.04-12.64)
Primer (n = 63)8.65 (0.42-82.71)0.9260.16 (0.001-2.01)0.697369 (20-3,373)0.3001.39 (0.04-12.64)0.936
Recurrent (n = 50)7.83 (0.17-101.83)0.24 (0.005-3.34)541 (7-3,126)0.91 (0.16-14.47)
Smoking
    Yes (n = 49)6.50 (0.42-82.71)0.7280.15 (0.005-2.01)0.247317 (30-3,373)0.3530.94 (0.04-11.47)0.195
    No (n = 54)7.39 (0.17-101.83)0.28 (0.005-3.34)481 (7-3,009)1.58 (0.11-14.47)
    Unknown (n = 10)
Control (n = 5)2.12 (0.98-7.89)0.03127.85 (6.89-46.53)<0.001530 (215-1,704)0.511.96 (1.40-5.22)0.106
Tumor (n = 113)8.08 (0.17-101.83)0.2 (0.001-3.34)396 (7-3,373)1.20 (0.04-14.47)