Table 2.

Cox univariate analysis

VariablesDisease-specific survivalMetastasis-free survivalRecurrence-free survival
HR (95% CI)PHR (95% CI)PHR (95% CI)P
Age, 71.6 (36-96), y0.850*0.177*0.779*
    ≤65 (n = 51)ReferenceReferenceReference
    >65 (n = 62)1.056 (0.601-1.855)0.8500.576 (0.256-1.297)0.1831.097 (0.574-2.093)0.780
Sex0.318*0.953*0.609*
    Male (n = 88)ReferenceReferenceReference
    Female (n = 25)0.728 (0.391-1.356)0.3160.971 (0.362-2.603)0.9530.816 (0.816-0.373)0.611
    Noninvasive (n = 48)Reference<0.001*Reference<0.001*Reference0.632*
    Invasive (n = 65)6.695 (3.000-14.942)<0.0019.115 (2.706-30.705)<0.0010.817 (0.356-1.875)0.633
Grade<0.001*0.005*0.618*
    Low-grade (n = 57)ReferenceReferenceReference
    High-grade (n = 56)3.8 (2.040-7.081)<0.0013.19 (1.539-7.483)0.0080.8 (0.332-1.928)0.620
Prior recurrence0.233*0.621*0.913*
    Primer (n = 63)ReferenceReferenceReference
    Recurrent (n = 50)1.414 (0.798-2.506)0.2350.812 (0.354-1.859)0.6220.965 (0.511-1.822)0.913
Smoking0.408*0.534*0.891*
    Yes (n = 49)ReferenceReferenceReference
    No (n = 54)0.788 (0.447-1.389)0.4101.298 (0.569-2.964)0.5350.951 (0.462-1.957)0.891
    Unknown (n = 10)
VEGF gene expression (n = 107)0.269*0.858*0.265*
    Not informative (n = 6)
    Low (n = 53)ReferenceReferenceReference
    High (n = 54)0.718 (0.398-1.295)0.2710.928 (0.409-2.105)0.8581.461 (0.746-2.862)0.269
    Noninvasive cases0.362*0.827*0.059*
    Low (n = 15)ReferenceReferenceReference
    High (n = 32)0.496 (0.107-2.300)0.3711.309 (0.116-14.719)0.8272.22 (0.947-5.200)0.066
    Invasive cases0.232*0.072*0.247*
    Low (n = 38)ReferenceReferenceReference
    High (n = 22)1.474 (0.776-2.789)0.2362.216 (0.910-5.392)0.080.311 (0.037-2.604)0.282
Ang-1 gene expression (n = 100)0.041*0.524*0.992*
    Not informative (n = 13)
    Low (n = 50)ReferenceReferenceReference
    High (n = 50)1.841 (1.017-3.332)0.0441.321 (0.560-3.119)0.5250.996 (0.472-2.102)0.992
    Noninvasive cases0.466*0.494*0.706*
    Low (n = 31)ReferenceReferenceReference
    High (n = 10)1.864 (0.341-10.199)0.4731.101 (0.230-1.160)0.6691.183 (0.494-2.836)0.706
    Invasive cases0.469*0.135*0.556*
    Low (n = 19)ReferenceReferenceReference
    High (n = 40)0.786 (0.409-1.512)0.4710.506 (0.203-1.260)0.1430.634 (0.134-3.004)0.566
Ang-2 gene expression (n = 108)0.051*0.038*0.048*
    Not informative (n = 5)
    Low (n = 53)ReferenceReferenceReference
    High (n = 55)0.563 (0.314-1.011)0.0540.4 (0.163-0.983)0.0461.985 (0.992-3.973)0.053
    Noninvasive cases0.974*0.808*0.009*
    Low (n = 16)ReferenceReferenceReference
    High (n = 31)0.975 (0.211-4.500)0.9741.346 (0.121-14.987)0.8093.178 (1.273-7.939)0.013
    Invasive cases0.598*0.270*0.420*
    Low (n = 37)ReferenceReferenceReference
    High (n = 24)0.84 (0.439-1.608)0.5990.567 (0.204-1.587)0.2770.432 (0.051-3.633)0.440
Tie2 gene expression (n = 103)0.890*0.585*0.681*
    Not informative (n = 10)
    Low (n = 52)ReferenceReferenceReference
    High (n = 51)0.96 (0.538-1.712)0.8900.795 (0.348-1.815)0.5861.154 (0.581-2.289)0.682
    Noninvasive cases0.997*0.977*0.886*
    Low (n = 28)ReferenceReferenceReference
    High (n = 15)1.004 (0.193-5.210)0.9971.037 (0.094-11.453)0.9771.057 (0.497-2.246)0.886
    Invasive cases0.035*0.034*0.793*
    Low (n = 24)ReferenceReferenceReference
    High (n = 36)0.511 (0.271-0.965)0.0390.395 (0.163-0.961)0.0411.259 (0.218-7.261)0.796
  • Abbreviation: 95% CI, 95% confidence interval.

  • * P values recorded are the results from log-rank tests.