Table 2.

Results of multivariate analyses with the Cox proportional hazard models

VariableOverall survivalProgression-free survival
HR (95% CI)PHR (95% CI)P
A
    CSC generation (vs no CSC generation)2.92 (1.37-6.20)0.0053.60 (1.69-7.68)0.0009
    Symptom duration ≤3 mo (vs >3 mo)2.39 (1.01-5.66)0.051.70 (0.80-3.64)0.17
    Partial surgery (vs complete surgery)2.92 (1.35-6.33)0.0073.36 (1.56-7.23)0.002
    Age1.05 (1.01-1.09)0.021.04 (1.00-1.07)0.05
    MGMT status negative (vs positive)1.04 (0.51-2.13)0.921.00 (0.50-1.96)0.99
    p53 status positive (vs negative)1.53 (0.60-3.90)0.371.03 (0.44-2.43)0.95
B
    CD133/Ki67 positive (vs negative)4.48 (1.68-11.9)0.0036.33 (2.48-16.2)0.0001
    Symptom duration ≤3 mo (vs >3 mo)4.18 (1.67-10.4)0.0023.14 (1.38-7.16)0.007
    Partial surgery (vs complete surgery)2.99 (1.34-6.65)0.0073.67 (1.67-8.05)0.001
    Age1.03 (0.98-1.07)0.231.02 (0.98-1.06)0.30
    MGMT status negative (vs positive)1.04 (0.50-2.14)0.920.94 (0.48-1.87)0.87
    p53 status positive (vs negative)1.20 (0.48-3.02)0.700.97 (0.43-2.18)0.93
C
    CD133 ≥2% (vs <2%)2.22 (1.09-4.52)0.032.10 (1.05-4.21)0.04
    Ki67 expression1.05 (1.00-1.10)0.031.05 (1.00-1.09)0.03
    Symptom duration ≤3 mo (vs >3 mo)2.57 (1.04-6.33)0.041.61 (0.72-3.60)0.25
    Partial surgery (vs complete surgery)3.07 (1.41-6.67)0.0052.73 (1.29-5.81)0.009
    Age1.07 (1.02-1.12)0.0031.05 (1.01-1.09)0.02
    MGMT status negative (vs positive)1.40 (0.66-2.97)0.391.36 (0.67-2.73)0.39
    p53 status positive (vs negative)1.65 (0.67-4.10)0.281.25 (0.52-3.00)0.62