Table 2.

VEGF genotype and haplotype frequencies among NSCLC cases and controls

CharacteristicsOverall
Male
Female
Cases (n = 1,900)Controls (n = 1,458)PCases (n = 981)Controls (n = 638)PCases (n = 919)Controls (n = 820)P
VEGF −460C/T, n (%)
    TT539 (28.4%)422 (28.9%)0.87287 (29.3%)179 (28.1%)0.79252 (27.4%)243 (29.6%)0.59
    CT922 (48.5%)694 (47.6%)473 (48.2%)307 (48.1%)449 (48.9%)387 (47.2%)
    CC439 (23.1%)342 (23.5%)221 (22.5%)152 (23.8)218 (23.7%)190 (23.2)
VEGF+405C/G, n (%)
    GG805 (42.4%)650 (44.6%)0.22397 (40.5%)279 (43.7%)0.14408 (44.4%)371 (45.2%)0.89
    CG848 (44.6%)644 (44.1)454 (46.3%)294 (46.1%)394 (42.9%)350 (42.7%)
    CC247 (13.0%)164 (11.3%)130 (13.3%)65 (10.2%)117 (12.7%)99 (12.1%)
VEGF +936C/T, n (%)
    CC1,441 (75.8%)1,125 (77.2%)0.67754 (76.9%)496 (77.7%)0.87687 (74.7%)629 (76.7%)0.63
    CT424 (22.3%)308 (21.2%)209 (21.3%)132 (20.7%)215 (23.4%)176 (21.5%)
    TT35 (1.8%)25 (1.7%)18 (1.8%)10 (1.6%)17 (1.9%)15 (1.8%)
Haplotypes*
    CGC40.0%40.8%0.2240.0%40.3%0.004140.1%41.7%0.40
    TCC28.1%29.1%27.6%31.4%28.2%26.8%
    TGC19.0%16.6%19.8%15.6%18.6%17.3%
    CGT6.5%6.0%7.0%6.1%6.1%5.6%
    TCT4.5%5.6%4.7%4.7%4.6%6.5%
  • * The combined haplotype frequencies (in the order of −460C/T, +405C/G, +936C/T) <5% were not included in the analysis.