Table 3.

Incidence of toxicity by genotype

GenotypePatients (%)
Grade 0/1Grade 2/3
TSER
    3RG/3RG4 (50)4 (50)
    3RG/3C and 3RG/2R10 (46)12 (55)
    Absence of 3RG10 (44)13 (57)
3′UTR indel
    6 bp/+6 bp9 (47)10 (53)
    +6 bp/−6 bp15 (52)14 (48)
    −6 bp/−6 bp1 (17)5 (83)
MTHFR 677
    CC11 (41)16 (59)
    CT8 (40)12 (60)
    TT6 (86)1 (14)
MTHFR 1298
    AA17 (68)8 (32)
    AC4 (17)19 (83)
    CC4 (67)2 (33)