Table 1.

Details ot DNA copy number alterations in MPNST samples

SI. NoSampleGradeDeleted genesAmplified genes
1M-1IntermediateFABP7, HMMR, HSPCA, MMP13, NF1,p16-INK4a,*BIRC5, CCNE2, CMA1, CCND1, EGFR, FLT4, HGF, ITGB4, MET, MMP9, PDGFRA, SPP1, TERT, TP73, TSC2
2M-2HighHMMR, NF1, p16-INK4a*CCNE2, HGF, ITGB4, MET, MMP9, PDGFRA, SPP1, TERT, TP73
3M-3UnknownHMMR, L1CAM2CCND1, RASSF2
4M-4IntermediateFABP7, HMMR, L1CAM2, MMP13, NF1, p16-INK4aBIRC5, CCNE2, CMA1, EGFR, HGF, ITGB4, MET, PDGFRA, SPP1, TERT, TP73
5M-5IntermediateHGF, HMMR, MET, NF1,OSF2, p16-INK4a, RASSF2, RB1, TNFRSF10A TP53 EGFR
6M-6UnknownFABP7, L1CAM2, MKi-67, mTOR, NF1, p16-INK4a*, PTCH2, PTEN, RASSF2, TIMP4BIRC5
7M-7HighHGF, HMMR HSPCA, L1CAM2, MET, NF1, OSF2, p16-INK4a, RASSF2, RB1EGFR, ITGB4, MMP9
8M-8HighHMMR, L1CAM2, MMP13, NF1, PTEN, RB1, TP53CCNE2, CCND1, EGFR, ERBB3, IL8, PDGFRA, SOX10
9M-9HighL1CAM2, NF1, p16-INK4aBIRC5, CCNE2, CCND1, EGFR, FLT4, FOS, FOXA2, HGF, ITGB4, MET, PDGFRA, SOX10, TERT, TGFB1, TP73, TSC1
10M-10HighL1CAM2, MMP13, mTOR, NF1, OSF2, p16-INK4a, PTCH2, RASSF2, RB1MDM4, MPZ
11M-11LowNF1, OSF2, RB1, TOP2ACDKN1A, CCND1, FLT4, FOXA2, Gl1, ITGB4, SOX10, TERT, TGFB1, TP73, TSC2
12M-12Low
13M-13High (Triton)HMMR, MMP13, mTOR, NF1, OSF2, p16-INK4a, PTCH2, RB1, TP53CCNE2, SOX10, TOP2A
14M-14UnknownFABP7, HMMR, HSPCA, Mki-67, MMP13, NF1, p16-INK4a, PTEN, TP53BIRC5, CCND1, EGFR, ITGB4, TERT, TOP2A
15M-15LowmTOR
16M-16HighMMP13, NF1BIRC5, ITGB4, MPZ, RASSF2, TSC2
17M-17LowNF1, TOP2AFOXA2
18M-18HighBIRC5, CCNE2, HGF, MET, PDGFRA
19M-19HighNF1CCND1, ITGB4, MMP9, PTCH2, SOX10, TERT, TP73, TSC2
20M-20HighEPHA7, FN1, HMMR, Mki-67, MMP13, NF1, P16-INK4a, RB1BIRC5, ITGB4, TERT
21M-21HighMki-67, mTOR, NF1, PTEN, SPP1HGF, MDM4, MET, MPZ, PDGFRA
22M-22HighFABP7, EPHA7, MKi-67, MMP13, RASSF2TOP2A
23M-23HighHMMR, MMP13, NF1, RASSF2, TP53
24M-24High
25M-25HighHMMR, HSPCA, Mki-67, MMP13, NF1, SPP1
26M-26HighHMMR, HSPCA, L1CAM2, MMP13, NF1, RASSF2mTOR
27M-27HighL1CAM2, RASSF2, RB
28M-28High
29M-29Unknown
30M-30UnknownMMP13, NF1, RASSF2, TP53BIRC5, CCNE2, CCND1, EGFR, FLT4, FOXA2, HGF, HSPCA, ITGB4, MDM4, MET, MTOR, PDGFRA, S100B, TERT, TOP2A, TP73
31M-31UnknownFABP7, HMMR, MMP13, NF1, OSF2, p16-INK4a, RB1CDKN1B/p27, FLT4, FOXM1, RASSF2
32M-32UnknownFN1, NF1, p16-INK4a, TOP2ABIRC5, CCND1, ITGB4
33M-33UnknownHMMR, L1CAM2, SPP1ITGB4
34M-34UnknownFABP7, EPHA7, MMP13, p16-INK4a, RB1, TNFRSF10A, TNFRSF10BFLT4, L1CAM2, SOX10
35M-35UnknownCCNE2, HMMR, HSPCAOSF2
  • * Homozygous deletion.

  • Partial deletion of the gene.

  • Partial homozygous deletion.