Table 3.

Cox regression analysis to estimate the adjusted hazard ratios of breast cancer subtypes defined by TNP and Core Basal method, respectively, on 3,558 cases with sufficient information for all of the variables

VariablesUnivariate analysis
Multivariate analysis
HR (95% CI)Nested Cox model HR (95% CI)Full Cox model HR (95% CI)
Age, y
    40-49 vs ≤400.62 (0.51-0.76)0.73 (0.59-0.91)0.74 (0.59-0.92)
    50-65 vs ≤400.65 (0.54-0.78)0.83 (0.68-1.01)0.84 (0.69-1.02)
    >65 vs ≤400.65 (0.54-0.78)0.87 (0.71-1.07)0.89 (0.72-1.09)
Grade
    3 vs (2 and 1)2.11 (1.86-2.39)1.49 (1.30-1.71)1.47 (1.28-1.69)
Lymphovascular invasion
    Positive vs negative2.28 (2.02-2.58)1.31 (1.13-1.53)1.32 (1.14-1.53)
Tumor size, cm
    2-5 vs ≤22.08 (1.84-2.36)1.65 (1.44-1.88)1.65 (1.44-1.88)
    >5 vs ≤23.32 (2.69-4.09)1.77 (1.38-2.27)1.77 (1.39-2.27)
Percentage of positive/dissected axillary lymph nodes
    0-25 vs 01.98 (1.70-2.31)1.62 (1.36-1.92)1.62 (1.37-1.93)
    >25 vs 03.99 (3.48-4.58)2.88 (2.44-3.40)2.89 (2.45-3.42)
Breast cancer subtype
    Luminal′ as reference
        Luminal/HER2+1.93 (1.55-2.40)1.41 (1.11-1.79)1.41 (1.12-1.79)
        HER2+/ER−PR−2.27 (1.86-2.76)1.88 (1.52-2.33)1.89 (1.53-2.34)
        Unassigned1.02 (0.81-1.29)1.12 (0.87-1.44)1.13 (0.99-1.45)
        TNP1.50 (1.28-1.74)1.39 (1.17-1.66)
        Core Basal1.77 (1.46-2.14)1.62 (1.31-2.00)
        5NP1.22 (0.97-1.52)1.16 (0.91-1.49)
  • NOTE: Hazard ratios above 1.0 indicate poorer outcome. Likelihood ratio test of TNP (nested model) and Core Basal (full model) methods has a P value of 0.0273. Hazard ratios for individual clinicopathologic variables in univariable breast cancer–specific survival listed for reference.