Table 3.

Univariate and multivariate analysis of prognostic factor and the relationship between clinicopathologic variables and pfetin expression

VariableNumber of casesMetastasis-free survivalTumor-specific survivalMultivariate analysis of metastasis free survival by Cox regressionPfetin positive (no. cases)Pfetin negative (no. cases)Correlation (pfetin) χ2 (P)
5 y (%)Log-rank (P)5-y (%)Log-rank (P)PRelative risk95% CI
Age0.32900.83500.5220
    <6011285.8 ± 3.791.8 ± 3.09319
    60<9880.7 ± 4.295.6 ± 2.27820
Sex0.44200.03930.8909
    F9986.5 ± 3.796.1 ± 2.28118
    M11180.4 ± 4.291.6 ± 2.89021
Site0.00010.16550.4776
    Stomach17087.8 ± 2.793.9 ± 2.014030
    Nonstomach4060.7 ± 9.292.2 ± 5.30.02702.211.09-4.49319
Histology0.10030.20680.5153
    Spindle18985.4 ± 2.893.6 ± 2.015534
    Epithelioid2167.7 ± 10.995.2 ± 4.6165
Size<0.0001<0.0001<0.0001
    <5 cm12892.4 ± 2.698.1 ± 1.311216
    5-10 cm6376.6 ± 0.493.7 ± 3.55112
    15 cm<1945.0 ± 11.960.5 ± 13.00.00702.051.22-3.44811
Necrosis<0.00010.00340.0070
    +1943.0 ± 12.776.9 ± 11.71030
    −19186.9 ± 2.795.1 ± 1.71619
Miosis<0.0001<0.0001<0.0001
    <5/50HPF*14895.5 ± 2.098.2 ± 1.313612
    5-10/50HPF3380.4 ± 7.296.8 ± 3.2267
    5/50HPF<2929.9 ± 9.068.2 ± 9.4920
MIB-1<0.0001<0.0001<0.0001
    <9%16496.0 ± 1.898.4 ± 1.115212
    10-29%1951.4 ± 12.685.6 ± 9.7118
    <30%2732.5 ± 9.670.8 ± 9.4819
Differentiation<0.0001<0.0001<0.0001
    Score 116195.9 ± 1.898.4 ± 1.114912
    Score 24943.5 ± 7.778.1 ± 6.6<0.000110.403.68-29.452227
Risk classification<0.0001<0.0001<0.0001
    Low11097.7 ± 1.698.9 ± 1.110010
    Intermediate4690.6 ± 5.297.0 ± 3.0442
    High5448.5 ± 7.480.6 ± 6.02727
Pfetin<0.0001<0.0001
    Positive17193.9 ± 2.097.2 ± 1.4
    Negative3936.2 ± 8.776.5 ± 7.90.00203.751.60-8.81
  • Abbreviation: 95% CI, 95% confidence interval.

  • * HPF, high-power field.