Table 4.

TTP and OS according to ERCC1, XPD, and CDA genotypes

GenotypeMedian TTP, mo (95% CI)PMedian OS, mo (95% CI)P
ERCC1 C118T
    C/C3.3 (1.3-5.2)0.098.8 (5.9-11.6)0.37
    C/T7.5 (4.8-10.2)16.7 (6.3-26.9)
    T/T6.1 (3.7-8.4)13.0 (6.9-19.1)
XPD Lys751Gln
    Lys/Lys6.1 (2.0-10.1)0.3810.0 (8.1-11.9)0.62
    Lys/Gln7.0 (4.0-9.9)13.0 (5.8-20.1)
    Gln/Gln5.0 (1.1-8.9)13.6 (9.7-17.5)
XPD Asp312Asn
    Asp/Asp6.1 (3.1-9.0)0.7210.0 (8.1-11.8)0.78
    Asp/Asn7.0 (3.2-10.8)12.6 (5.3-19.8)
    Asn/Asn5.0 (2.5-5.0)13.6 (0.0-29.0)
CDA Lys27Gln
    Lys/Lys8.4 (6.7-10.2)0.00617.0 (5.9-28.1)0.002
    Lys/Gln5.0 (3.2-6.8)13.6 (5.0-22.1)
    Gln/Gln3.3 (2.7-4.0)4.1 (2.1-6.1)