Table 3.

Univariate and multivariate Cox analysis of ieTIL subtypes, HLA-A, MICA, and clinicopathologic variables

VariableHR (95% CI)P
Univariate Cox analysis
    Lymph node statusPositive vs negative6.44 (2.79-14.82)0.001
    Tumor size (mm)≥40 vs <407.77 (2.85-21.16)0.001
    VasoinvasionPositive vs negative3.11 (1.36-7.11)0.007
    Infiltration depth (mm)≥15 vs <154.56 (1.80-11.60)0.001
    TregHigh vs low number2.76 (1.01-7.55)0.048
    CD8+/Treg ratioLow vs high ratio2.82 (1.09-7.27)0.032
    HLA-AWeak vs strong expression2.87 (1.04-7.95)0.042
Multivariate Cox analysis: single variables
    Lymph nodesPositive vs negative3.38 (1.16-9.83)0.025
    Tumor size (mm)≥40 vs <405.39 (1.89-67.05)0.002
    VasoinvasionPositive vs negative1.14 (0.42-3.08)0.800
    Infiltration depth (mm)≥15 vs <152.69 (0.76-9.36)0.126
    CD8+/Treg ratioLow vs high ratio2.71 (1.01-7.26)0.047
    Treg*High vs low number2.25 (0.67-7.50)0.187
    HLA-A*Weak vs strong expression2.70 (0.90-8.12)0.077
Multivariate Cox analysis: HLA-A + MICA
    Lymph nodes3.48 (1.15-10.52)0.027
    Tumor size6.70 (2.38-18.91)0.0003
    Vasoinvasion1.36 (0.52-3.59)0.534
    Infiltration depth1.97 (0.64-6.08)0.240
    HLA-A + MICAWeak expression vs rest4.04 (1.61-10.13)0.003
Multivariate Cox analysis: HLA-A + MICA + CD8+/Treg
    Lymph nodes2.15 (0.67-6.90)0.199
    Tumor size6.21 (2.13-18.12)0.001
    Vasoinvasion1.32 (0.48-3.62)0.588
    Infiltration depth2.97 (0.80-11.04)0.105
    HLA-A + MICA + CD8+/TregWeak expression/low ratio vs rest4.91 (1.82-13.22)0.002
  • Abbreviation: 95% CI, 95% confidence interval.

  • * Variables were analyzed in separate multivariate analyses as not to influence each other's HR.