Table 2.

Comparison of the total UKCAP trial population and patients genotyped in this study

VariableUKCAP trial populationGenotyped patients
n853546
Age*
    Mean (y)57.557.3
    SD9.39.3
Sex, n (%)
    Male477 (56)289 (53)
    Female376 (44)256 (47)
Intervention, n (%)
    Folate alone215 (25.2)144 (26.4)
    Aspirin alone217 (25.4)131 (24.0)
    Folate and aspirin217 (25.4)135 (24.7)
    Double placebo204 (23.9)136 (24.9)
Colonoscopy interval
    Mean (mo)40.340.7
    SD (mo)12.211.7
    Range (mo)2-796-74
Outcome, n (%)
    Adenoma207 (24.2)130 (23.8)
    Carcinoma11 (1.3)7 (1.3)
    Advanced neoplasia104 (12.2)70 (12.8)
  • * Age at entry colonoscopy.

  • Interval between entry and follow-up colonoscopy (mean, SD, and range).

  • Follow-up colonoscopy outcome definitions were as follows: “adenoma,” histologically confirmed colorectal adenoma; “carcinoma,” histologically confirmed colorectal carcinoma; and “advanced neoplasia,” colorectal adenoma ≥1 cm diameter, villous or tubulovillous histology, severe dysplasia, or colorectal carcinoma.