Table 2.

IC50 values for cell viability, ErbB2 phosphorylation, and ERK phosphorylation

Ba/F3 cell lineResistance mutationSurvival IC50 (nmol/L)
pErbB2 IC50 (nmol/L)
pERK IC50 (nmol/L)
LapatinibEXEL-7647LapatinibEXEL-7647LapatinibEXEL-7647
V659ENone961487429831,259559
V659E_L755SL755S2,8613713,6109549,3751,248
V659E_L785FL785F1,1545543,9183,34110,1075,966
V659E_T798IT798I3,339419>30,0003,267>30,0003,296