Table 3.

Comparison of changes in LOH and histopathologic grade

LocusEvents of LOH ↓ (improvement)
Events of LOH ↑ (progression)
Events of LOH unchanged (no effect)
Histopathologic Δ*
3p149p21-2217p133p149p21-2217p133p149p21-2217p13
Patient no.
    14 (100)−1
    21 (100)−1
    31 (100)−1
    52 (100)−1
    60
    71 (16.7)2 (33.3)1 (16.7)2 (33.3)0
    82 (18.2)2 (18.2)4 (36.3)3 (27.3)3
    9−1
    105 (83.3)1 (16.7)−2
    112 (25)6 (75)1
    121 (16.7)2 (33.3)2 (33.3)1 (16.7)0
    131 (50)1 (50)0
    14−1
    150
    172 (50)2 (50)1
    184 (100)0
    191
  • NOTE: For each column, the number of changes in LOH at a particular locus is given for each patient followed by the percentage, in parenthesis, of the total number of LOH events identified in that patient. LOH events listed include alterations at both the biopsy site and the residual lesion site. Blank spaces indicate that no LOH was identified.

  • * A negative value indicates a decrease (improvement) in grade, whereas a positive value indicates an increase (progression) in grade. The values also reflect the magnitude of grade alteration. A zero value signifies that no change in grade was observed.