Table 1.

Patient clinical characteristics

Total (N = 23)
Sex
    Female, n (%)8 (35)
Age, y
    Median67
    Range60-83
Diagnosis, n (%)
    AML12 (52)
    MDS11 (48)
MDS IPSS score, n (%)
    Intermediate 15 (45)
    Intermediate 25 (45)
    High1 (10)
ECOG performance status, n (%)
    09 (39)
    113 (57)
    21 (4)
Time from diagnosis to first dose, wk
    Median38
    Range5-357
Prior treatment, n (%)
    None4 (17)
    Hydroxyurea only2 (9)
    ESA only1 (4)
    Combination chemotherapy13 (57)
No. prior chemotherapy regimens
    Median2
    Range1-5
Bone marrow blasts at screening visit
    Median17
    Range1-96
  • Abbreviations: ECOG, Eastern Cooperative Oncology Group; IPSS, International Prognostic Scoring System; ESA, erythropoiesis-stimulating agents.