Table 3.

Compiled grade 3 and 4 adverse event

AML (n = 12)
MDS (n = 11)
All patients (N = 23)
Grade 3Grade 4Grade 3Grade 4Grade 3Grade 4
Blood/bone marrow*
    Anemia305080
    Leukopenia003030
    Lymphopenia101020
    Neutropenia210021
    Thrombocytopenia101121
Constitutional
    Fatigue002020
    Fever100010
    Infection312051
Cardiovascular
    Hemorrhage100010
    Hypertension100010
    Hypotension100010
    Syncope100010
Digestive system
    Diarrhea100010
    Gingivitis100010
    Ileus100010
    Nausea101020
    Vomiting101020
Metabolic
    AST001010
Musculoskeletal
    Bone pain001010
Pain
    Abdominal100010
    Neck001010
Pulmonary
    Dyspnea101020
    Epistaxis200020
  • Abbreviation: AST, aspartate aminotransferase.

  • * Only in patients without grade 3 or 4 baseline cytopenias.

  • Dose-limiting toxicities.