Table 4.

Univariate and multivariate analysis in colorectal cancer patients

Univariate analysis
Multivariate analysis
DFS (mo)95% CIPHazard ratio (95% CI)P
115 patients
5-FU AUC
    <8.4 h × mg/L34.7(9.5-59.9)0.021 (Reference)0.06
    ≥8.4 h × mg/LNR0.59 (0.33-1.04)
Status N
    0NR0.0091 (Reference)0.12
    140.5n.d.1.51 (0.78-2.91)
    218.4(4.8-32.0)2.18 (1.04-4.57)
Treatment completed
    YesNR0.00011 (Reference)0.001
    No16.4(12.4-20.4)2.91 (1.55-5.45)
101 patients
5-FU AUC
    <8.4 h × mg/L45.3n.d.0.021 (Reference)0.07
    ≥8.4 h × mg/LNR0.54 (0.28-1.05)
Status N
    0NR0.0051 (Reference)0.03
    1NR1.74 (0.81-3.73)
    214.0(0.0-32.8)3.11 (1.36-7.12)
  • Abbreviatons: NR, not reached; n.d., not determined; 95% CI, 95% confidence.