Table 2.

Immunohistochemistry/immunoblotting evaluations

DiagnosisClinical response/TTP, moKIT IHC (LL), %KIT IHC (CL), %KITpKITPDGFRApPDGFRAPDGFRBpPDGFRBpAKTpMAPKpSTAT3
AFPD/2.8>505+++++++++++
AFSD/12.5>50>50+++++++++++
AFPR/17.0>50>50++
AFPD/1.0>50>50+++++++++
ChondrosarcomaPD/1.2>50ND++++++
DFSPCR/33.0+ND0+++++++++++++
DFSPUNK/0.0+NDND+++++++++
DFSPPR/23.900+++++++
DFSPPR/1.9+ND0++++++++
HemangiopericytomaPD/1.550ND++++
LiposarcomaSD/15.2>50ND+++++++++++++++
LiposarcomaPD/1.2>500++++++++++++
LiposarcomaSD/16.5+>500++
Liposarcoma—dediffPD/0.8>500+++++++++
Liposarcoma—dediffSD/2.8+>50ND+++
LiposarcomaPD/2.60ND++++
LeiomyosarcomaPD/2.6NDND++++++++++++
LeiomyosarcomaUNK/5.1>500
LeiomyosarcomaPD/1.0>500+++++++
LeiomyosarcomaPD/1.0>50ND+++++++++++++
Malignant SchwannomaUNK/1.0+0ND+
Malignant SchwannomaPD/1.0>500+
Mast cell leukemiaSD/1.4>50>50++++++
MelanomaPD/1.0>50>50+++++++
Intraocular MelanomaPD/2.3>50ND
MesenchymomaPD/1.4>50ND+++
MesotheliomaUNK/0.0+>50ND+++
MyelomaPD/3.0>50ND++
MyelomaPD/1.0>50ND+++++++
MyelomaPD/1.0>50ND++
Renal cell carcinomaPD/1.4>50ND++++
RhabdomyosarcomaPD/1.0>50>50
RhabdomyosarcomaPD/1.0>5020+++++++
RhabdomyosarcomaPD/1.0>5020++++++++++++
RhabdomyosarcomaPD/2.7>505++++++++++
  • NOTE: A time to progression value with the symbol “+” indicates a censored time to event.

    Abbreviations: ND, not done; UNK, unknown; IHC, immunohistochemistry; LL, local pathology laboratory; CL, central pathology laboratory; AF, aggressive fibromatosis; DFSP, dermatofibrosarcoma protuberans; MAPK, mitogen-activated protein kinase; STAT3, signal transducer and activator of transcription 3.