Table 1.

Aberrantly spliced variants of Hugl-1 in HCC

No.CaseNo. aberrantly spliced variantsNucleotide changeCausing frameshiftName of Hugl-1 splice variants
1DF601369-1442 deletedNoHugl-1/Δ369-1442
2DF1851408-1618 deletedYesHugl-1/Δ408-1618
3DF1711426-1576 deletedYesHugl-1/Δ426-1576
4DF991496-1680 deletedNoHugl-1/Δ496-1680
5DF1351705-1820 deletedNoHugl-1/Δ705-1820
6DA831776-778 deletedNoHugl-1/Δ773-775
7DA1041776-778 deletedNoHugl-1/Δ773-775
8DA1791776-778 deletedNoHugl-1/Δ773-775
9DA911776-928 deletedNoHugl-1/Δ776-928
10DA9211028-1345 deletedNoHugl-1/Δ1028-1345
11DA13811028-1345 deletedNoHugl-1/Δ1028-1345
12DF10911054-1690 deletedYesHugl-1/Δ1054-1690
13DF14511196-1492 deletedNoHugl-1/Δ1196-1492
14DF18711196-1492 deletedNoHugl-1/Δ1196-1492
15ZS1111196-1492 deletedNoHugl-1/Δ1196-1492
16DF12611673-1965 deletedYesHugl-1/Δ1673-1965
17DA9312268-2828 deletedNoHugl-1/Δ2268-2828
18DA1282153-1688 deletedNoHugl-1/Δ153-1688
176-1857 deletedYesHugl-1/Δ176-1857
19DF1722343-1816 deletedYesHugl-1/Δ343-1816
477-1753 deletedYesHugl-1/Δ477-1753
20DF1042776-1327 deletedNoHugl-1/Δ776-1327
1414-1567 and 1673-1965 deletedYesHugl-1/Δ1414-1567/1673-1965
21DL3711414-1567 and 1673-1965 deletedYesHugl-1/Δ1414-1567/1673-1965
22DF10511414-1567 and 1673-1965 deletedYesHugl-1/Δ1414-1567/1673-1965
23DA 14312268-2828 and 2896-3017 deletedYesHugl-1/Δ2268-2828/2896-3017
24DF451776-1345 and 1414-1567 and 1673-1965 deletedYesHugl-1/Δ776-1345/1414-1567/1673-1965
25DL27138 bp inserted between 453 and 454YesHugl-1/INS38
26DF182167 bp inserted between 891 and 1966YesHugl-1/INS71
27SMMC-772111190-1508 deletedYesHugl-1/Δ1190-1508
DG80*1414-1567 and 1673-1965 deletedYesHugl-1/Δ1414-1567/1673-1965
  • NOTE: RNA from HCC and matched noncancerous tissue specimens from 80 HCC patients and 5 HCC cell lines were analyzed.

  • * A patient not included in the statistical analysis.