Table 1.

Gene promoter hypermethylation

RASSF1AHIN1TWIST1CYCLIN D2APC1RAR βCDH1BRCA1BRCA2ER αP16
Cancer
    No. of values77777766777
    25% percentile1.080.800.450.110.100.060.010.000.000.000.00
    Median1.841.955.231.210.262.520.170.000.000.000.00
    75% percentile35.0040.3230.9537.6616.0914.454.190.830.000.000.33
    Mean13.9215.6918.0215.3110.239.962.630.400.000.010.99
Papilloma
    No. of values2726272725272227272627
    25% percentile0.000.000.000.000.000.090.000.000.000.000.00
    Median0.440.020.030.010.001.070.000.000.000.000.00
    75% percentile1.420.680.110.310.252.070.100.000.000.000.00
    Mean3.271.330.610.541.561.463.592.400.010.010.00
Normal
    No. of values2828282828282227282828
    25% percentile0.000.000.000.000.000.140.000.000.000.000.00
    Median0.050.000.030.260.010.940.000.000.000.000.00
    75% percentile0.520.010.530.650.252.050.020.000.000.000.00
    Mean0.290.150.350.530.281.400.050.000.050.020.00
P
    Normal vs cancer0.0010.0000.0020.0610.0620.3120.0200.0220.0200.3970.130
    Papilloma vs cancer0.0170.0190.0010.0090.0340.3940.1370.2170.1370.3230.283
    Normal vs papilloma0.1670.0850.9460.1850.2040.8660.3830.2860.3830.8240.197
  • NOTE: Cells were harvested during ductoscopy and the % methylation was determined by QM-MSP. Shown is the median, quartiles, and mean level of % methylation for 11 genes (P values calculated by the Mann-Whitney U Test).