Table 1.

IC50 of TubA, CDP-TubA, 2-mercaptoethyl amide of TubA, and TubA-SS-TubA in human HT29 colorectal, human A2780 ovarian, and human H1299 non–small cell lung carcinoma cells

Cell lineTubA (nmol/L)CDP-TubA (nmol/L)2-mercaptoethyl amide of TubA (nmol/L)TubA-SS-TubA (nmol/L)
HT291.34.94.42.5
A27801.69.78.74.1
NCI-H12992.823.719.06.6
  • NOTE: All IC50 values were acquired in a 48 h MTS assay and are expressed in tubulysin monomer equivalents.