Table 2.

Combination studies involving new generation HDACi

New generation HDACiStudyCombinationDiseasePhaseNumberResponse
Demethylation/HDACiGarcia-Manero et al (67)Aza/MGCD0103AML/MDSI24CR 3, CRi 3, PR 1
Silverman et al (68)Aza/vorinostatAML/MDSI20CR 5, CRi 1, HI 3,
Gore et al (69)Aza/MS-275AML/MDSI31CR 2, PR 4, HI 6
Odenike et al (70)Aza/belinostatAML/MDS/MFI21CR 2, PR 1, HI 4
Bortezomib/HDACiWeber et al (30)Bort/vorinostatMMI34PR 9, MR 7, SD 18
Badros et al (29)Bort/vorinostatMMI23VGPR 2, PR 7, SD 10
Siegel et al (58)Bort/panobinostatMMI14PR 3
Harrison et al (42)Bort/romidepsinMMI22CR 3, VGPR 3, PR 6, MR 5
  • Abbreviations: MF, myelofibrosis; Bort, bortezomib; CR, complete response; HI, hematologic response.