Table 1.

Univariate and multivariate Cox proportional hazards analysis for TDM

Univariate analysis
Multivariate analysis
No. samplesHR (95% CI)P*No. samplesHR (95% CI)P*
PITX2P2 methylation2411.66 (1.21-2.28)0.0022001.28 (1.03-3.83)0.026
Age at surgery2411.00 (0.75-1.32)0.9812001.01 (0.98-1.04)0.7
T stage (T2,T3 vs T1)§2391.77 (1.08-2.91)0.0232001.47 (0.84-2.59)0.18
PgR status (positive vs negative)§2410.77 (0.43-1.36)0.3672001.11 (0.54-2.31)0.77
Endocrine treatment (yes vs no)§2390.49 (0.30-0.78)0.0032000.58 (0.33-1.00)0.052
Grade (1/2 vs 3)§2032.07 (1.27-3.83)0.0042001.68 (1.00-2.81)0.049
  • * P values refer to LRT for univariate analysis and Wald test for multivariate analysis.

  • PITX2P2 methylation and age at surgery were analyzed as continuous variables (95% CI), and HRs were calculated relative to an increment from the lower quartile to the upper quartile.

  • Significant feature.

  • § T stage, endocrine treatment, PgR status, and grade were analyzed as binary variables.