Table 2.

DNA methylation markers in ER-positive, HER-2-negative patients that meet the 5% false discovery rate limit for TDM

No.GeneUnivariate analysis
Multivariate analysis
C indexP*C indexP*
1BMP40.632<0.00010.6800.0002
2FOXL20.6320.00010.6400.02
3LMX1A0.6170.00080.6350.068
4C20orf550.5920.00090.6370.001
5BARX10.6130.00150.6240.1
6PLAU Amp20.5980.00170.6200.12
7FGF40.6190.00190.6460.029
8NR5A10.6090.00270.6350.059
9BRCA10.6310.00280.6470.018
10TLX30.5830.00320.6340.008
11NR2E10.5920.00540.6430.02
12LHX40.5760.00760.6210.12
13PLAU Amp10.5850.00780.6350.051
14ZNF1A10.5940.0080.6360.044
15CCND20.5980.010.6310.067
  • NOTE: For all variables, except C20orf55, low methylation scores were associated with long TDM. Multivariate analyses were done including the respective amplificate as well as age at surgery, T stage, endocrine treatment PgR, and grade.

  • * P values refer to LRT for univariate analysis and Wald test for multivariate analysis (not corrected for multiple testing).

  • C index of multivariate model with clinical variables alone (age at surgery, T stage, PgR, endocrine treatment, and grade) was 0.61.