Table 3.

Predictive performance estimated from multivariate Cox proportional hazards analysis for TDM

Features in Cox model (TDM)C indexP (LRT)
Age at surgery, T stage, PgR, endocrine treatment, grade0.610.01
PITX2P20.6240.0019
Age at surgery, T stage, PgR, endocrine treatment, grade, PITX2P20.6470.0029
Four-marker panel0.668<0.00001
Age at surgery, T stage, PgR, endocrine treatment, grade, four-marker panel0.69<0.00001
  • NOTE: T stage, endocrine treatment, PgR status, and grade were analyzed as binary variables. PITX2P2 methylation score and age at surgery were continuous variables. For the four-marker panel, the cross-validated prediction score was used as a continuous variable. LRT P values as well as the C index (bootstrap corrected) are calculated for each Cox model.