Table 2.

Serum levels of PGE2, LTB4, and 8-isoprostane from Sprague-Dawley rats fed control diet or mixed tocopherols diet

Group*PGE2 (pg/mL)LTB4 (pg/mL)8-Isoprostane (pg/mL)
AIN-93M control diet7,658.6 ± 1820.5686.0 ± 78.1287.5 ± 58.8
0.1% mixed tocopherols in AIN-93M diet8,898.7 ± 1676.0714.7 ± 47.9290.4 ± 71.5
0.3% mixed tocopherols in AIN-93M diet8,443.1 ± 1573.2700.9 ± 49.0248.4 ± 40.6
0.5% mixed tocopherols in AIN-93M diet8,348.5 ± 1045.7680.8 ± 30.6255.1 ± 35.4
  • * All rats (21 ± 1 d old, n = 12 per group) were given an i.p. injection of 50 mg NMU per kilogram body weight 1 wk before starting the feeding of mixed tocopherols. Rats were fed with control or mixed tocopherol containing diet for 9 weeks. Serum samples were collected at autopsy and analyzed for the levels of PGE2, LTB4 and 8-isoprostane.

  • The data are expressed as mean ± S.E. (n = 6). There is no significant difference among groups by statistical analysis.