Table 3.

Changes in peripheral blood effector cell levels following 7 days of lenalidomide therapy in 16 patients with WM

Peripheral blood effector cellsBaseline levelPost-7 days lenalidomideP
Lymphocytes1,185 (740-7,260)770 (400-12,560)0.87
Monocytes630 (110-1,320)520 (10-1,900)0.62
CD3+827 (310-2,066)436 (284-6,028)0.89
CD4+536 (140-1603)273 (55-7,132)0.76
CD8+273 (131-856)180 (64-1,632)0.80
CD4/CD8 ratio1.68 (0.46-6.55)1.87 (0.39-9.71)0.94
CD16+/CD56+208 (37-392)259 (4-1,005)0.51
  • NOTE: Levels were determined before administration of first rituximab infusion. Median (range) for absolute circulating levels of total lymphocytes, monocytes, CD3+, CD4+, CD8+, and CD16+/56+ cells.