Table 2.

Cycles administered by drug and dose level

DLnPemetrexed/cisplatin dose (mg/m2)Cycles administered, median (range)Pemetrexed
Cisplatin
Planned dose, mean (mg/m2/wk)*Delivered dose, mean (mg/m2/wk)Percentage of planned dose (delivered/planned)Planned dose, mean (mg/m2/wk)*Delivered dose, mean (mg/m2/wk)Percentage of planned dose (delivered/planned)
13500/753.0 (2-6)166.7156.794.025.023.393.3
23600/755.0 (1-6)200.0200.1100.125.025.2100.7
33700/754.0 (4-4)233.3231.199.125.024.999.5
46800/755.5 (2-6)266.7238.289.325.023.091.8
56900/753.0 (1-6)300.0272.690.925.022.891.0
  • Abbreviation: DL, dose level.

  • * Planned mean dose = dose divided by 3 wk.

  • Delivered mean dose = total dose divided by weeks on study.

  • Of the 14 cycle delays in this study, 12 occurred in dose levels 4 and 5, including 7 delays due to scheduling conflict and 1 delay due to inadequate folic acid compliance. The cycle delays contributed to the lower dose intensity seen in these two dose levels.