Table 2.

Multivariate analysis for RS transformation

HR95% CIP
Biological and clinical variables*
    IGHV4-394.031.57-10.320.004
    Stereotyped HCDR33.331.63-6.800.001
    CD38 expression ≥30%3.341.61-6.920.001
Interaction analysis
IGHV4-39 stereotyped HCDR3 interaction4.761.76-12.880.002
    Stereotyped HCDR33.111.50-6.480.002
    CD38 expression ≥30%3.161.50-6.640.002
  • Abbreviation: P, P value calculated by Cox analysis.

  • * Covariates at CLL diagnosis that entered the analysis were IGHV4-39 usage versus no IGHV4-39 usage, stereotyped HCDR3 versus no stereotyped HCDR3, IGHV gene homology ≥98% versus IGHV gene homology <98%, CD38 expression ≥30% versus CD38 expression <30%, and Rai stage 0-II versus Rai stage III-IV.

  • Covariates at CLL diagnosis that entered the analysis were IGHV4-39 usage versus no IGHV4-39 usage, stereotyped HCDR3 versus no stereotyped HCDR3, IGHV gene homology ≥98% versus IGHV gene homology <98%, CD38 expression ≥30% versus CD38 expression <30%, and Rai stage 0-II versus Rai stage III-IV, and IGHV4-39 stereotyped HCDR3 interaction.