Table 2.

Statistical results, hazard analysis for metastasis-free survival, time to local failure, and overall survival

ParameterMFSTLFOS
I.CHR (95% CI)PHR (95% CI)PHR (95% CI)P
Pre (n = 37)
    GradeH vs L1.63 (1.1-2.4)0.0101.36 (0.8-2.3)0.2301.65 (1.1-2.4)0.008
    Volume27.9 cm31.15 (1.0-1.3)0.0491.05 (0.8-1.3)0.6201.16 (1.0-1.3)0.040
    AUC600.30.80 (0.6-1.1)0.2200.88 (0.6-1.4)0.5820.81 (0.6-1.2)0.247
    AUC900.30.80 (0.6-1.1)0.2090.87 (0.6-1.4)0.5620.81 (0.6-1.1)0.234
    AUCt-max0.30.89 (0.7-1.1)0.3100.66 (0.5-0.9)0.0200.89 (0.7-1.1)0.320
    Washin0.10.89 (0.7-1.1)0.3310.86 (0.6-1.2)0.3810.89 (0.7-1.1)0.338
    Washout1.40.68 (0.5-0.9)0.0150.87 (0.6-1.3)0.5000.67 (0.5-0.9)0.012
Post (n = 17)
    AUC600.30.44 (0.3-0.7)0.0010.84 (0.5-1.5)0.5400.49 (0.3-0.8)0.001
    AUC900.30.45 (0.3-0.7)0.0010.85 (0.5-1.5)0.5500.49 (0.3-0.8)0.001
    AUCt-max0.40.46 (0.3-0.8)0.0020.65 (0.4-1.2)0.1700.46 (0.3-0.8)0.001
    Washin0.10.55 (0.4-0.9)0.0040.76 (0.5-1.3)0.2700.53 (0.3-0.8)0.002
    Washout1.70.82 (0.5-1.3)0.4141.16 (0.6-2.1)0.650.82 (0.5-1.3)0.402
pH
    pHi-Pre (n = 30)H vs L0.54 (0.2-1.3)0.1500.49 (0.2-1.5)0.1990.58 (0.3-1.3)0.199
    pHi@24 h-pHi-Pre (n = 15)H vs L1.44 (0.5-4.6)0.5387.70 (0.9-66.2)0.0631.41 (0.4-4.5)0.565
    pHe-Pre (n = 30)H vs L0.29 (0.1-0.7)0.0050.84 (0.27-2.60)0.7670.36 (0.2-0.8)0.013
    pHe@24 h-pHe-Pre (n = 24)H vs L2.87 (1.1-7.6)0.0341.59 (0.5-5.5)0.4652.54 (1.0-6.7)0.061
HTmin
    Total duration of heat (min)1.28 (1.1-1.5)0.0071.18 (0.9-1.5)0.1491.32 (1.09-1.60)0.004
  • NOTE: Summary of Cox proportional hazard ratio analysis showing significant perfusion/permeability predictors of clinical outcome determined with signal-based DCE-MRI. The pre-washout rate was predictive for metastasis-free and overall survival, whereas AUCt-max was predictive in time to local failure. For the post-image analysis, all the AUC calculation and the washin rates were predictive of metastasis-free and overall survival. The pre-pHe, the difference in pHe between pretherapy and posttherapy, and heating duration were also predictive of metastasis-free and overall survival.

    Abbreviations: OS, overall survival; MFS, metastasis free survival; TLF, tumor local failure; I.C, incremental change (of respective unit); HR, hazard ratio; 95% CI, 95% confidence interval; AUC60, AUC integrated up to 60 s; AUC90, AUC integrated up to 90 s; AUCt-max, AUC integrated up to time to muscle peak.