Table 1.

Clinicopathologic characteristics of ALK-rearranged and ALK germ-line NSCLC

CharacteristicsALK rearrangementALK germ-lineP
No. cases20 (6)338 (94)
Sex, n (%)
    Male11 (55)127 (38)0.16
    Female9 (45)211 (62)
Age (y), median (range)51 (29-76)66 (29-90)0.0002
Smoking status, n (%)
    Never smoker14 (70)71 (21)<0.0001
    Smoker6 (30)237 (70)
    Unknown30 (9)
Tumor status,* n (%)
    pT14 (20)103 (30)0.15
    pT22 (10)119 (35)
    pT30 (0)10 (3)
    pT40 (0)37 (11)
    Not evaluated14 (70)69 (20)
Lymph node status,* n (%)
    Negative4 (20)176 (52)0.13
    Positive6 (30)81 (24)
    Not evaluated10 (50)81 (24)
Stage,* n (%)
    I4 (15)165 (49)0.0001
    II0 (0)29 (9)
    III0 (0)67 (20)
    IV16 (85)77 (23)

NOTE: Due to rounding not all percentages total 100.

  • *Tumor and node status were based on pathology evaluation (pStage). Stage was based on both radiology and pathology evaluation (cStage).